Hepatitis B Immunoglobulin and Lamivudine Improve Hepatitis B–Related Outcomes After Liver Transplantation: Meta-Analysis
نویسندگان
چکیده
منابع مشابه
Is Hepatitis B Immunoglobulin Necessary in Prophylaxis of Hepatitis B Recurrence after Liver Transplantation? A Meta-Analysis
BACKGROUND & AIMS Application of nucleoside analogues and hepatitis B immunoglobulin (HBIG) has reduced hepatitis B virus (HBV) recurrence rate after liver transplantation (LT) dramatically. Recent data suggests therapy without HBIG is also effective. We sought to evaluate the necessity of HBIG in prophylaxis of HBV recurrence after LT. METHODS A meta-analysis was performed. PubMed/MEDLINE, W...
متن کاملNatural history of hepatitis B and outcomes after liver transplantation.
HBV infection is the single most common cause of cirrhosis globally although the prevalence rate is influenced by geographic region. The natural course of HBV infection and the clinical outcome is dependent on the interplay between host, virus, and environmental factors. Understanding the natural history of HBV infection is important in determining treatment strategies. OLT is the ultimate cure...
متن کاملHepatitis B and liver transplantation.
Liver transplantation is the treatment of choice for patients with liver failure secondary to chronic hepatitis B. However, liver transplantation is complicated by the risk of recurrent hepatitis B virus infection, which significantly impairs graft and patient survival. The main risk factor for the development of recurrent hepatitis B virus infection is the virus load at the time of transplanta...
متن کاملA multicenter study of lamivudine treatment in 33 patients with hepatitis B after liver transplantation.
Hepatitis B virus (HBV) infection after liver transplantation (LT) may lead to severe and rapidly progressive graft failure. Antiviral treatment may be of benefit in selected patients with recurrent hepatitis B post-LT. The aim of this prospective open-label study is to determine the safety and efficacy of lamivudine in 33 liver transplant recipients with active HBV infection. The median time f...
متن کاملEffectiveness of lamivudine in treatment of acute recurrent hepatitis B after liver transplantation.
In spite of long-te rm prophylaxis with hepatitis B immune globulin (HBIG), recurrence of hepatitis B virus (HBV) infection in the graft constitute s the leading cause of morbidity and mortality among patients unde rgoing liver transplantation (LT) due to HBV-induced live r cirrhosis (1). In many of these patients acce lerated HBV replication overcomes the protective effect of HBIG (2). Inte rf...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Gastroenterology and Hepatology
سال: 2008
ISSN: 1542-3565
DOI: 10.1016/j.cgh.2008.02.055